Second-place Argentina beat Peru 1-0 a few hours earlier and is also close to clinching a direct qualifying berth. Lionel Messi did not have one of his better days, but the hosts managed to have the best opportunities in the match.
Brazil has 31 points, more than any team that advanced in four South American qualifiers since the current format was established in 2002.
A win against Colombia in Sao Paulo in November will advance Brazil to Qatar with several qualifying matches in hand.
Argentina has 25 points, and both teams have played 11 matches.
The encounter between the two rivals in September was suspended after seven minutes of play due to COVID-19 protocols. FIFA has not yet decided whether the match will be re-played.
Ecuador remains in third spot with 17 points after a 0-0 draw at Colombia, which has 16 points in fourth, marginally ahead of Uruguay.
ARGENTINA 1, PERU 0
Argentina wasted two opportunities to score in the first two minutes of the match. And it appeared it would hammer Peru when Lautaro Martinez opened the scoring with a headed goal in the 43rd minute after a cross from the right by Nahuel Molina.
But the second half showed a more intense Peru team, which had a golden chance to equalize from the spot in the 65th minute after a foul by goalkeeper Emiliano Martinez. But veteran Yoshimar Yotun hit the bar.
Martínez said Argentina had more difficulties against Peru in comparison with the 3-0 win over Uruguay on Sunday.
Our game was more fluid against Uruguay, there were more gaps,” Martinez said. “We had a few difficulties, but we managed to always find a solution. Today we did find it.”
Also on Thursday, Chile rose to sixth position with 13 points after a 3-0 home win against bottom-of-the-table Venezuela. Erick Pulgar scored twice and Ben Brereton scored the third for the hosts.
Bolivia beat Paraguay 4-0 in La Paz, causing their rivals to fire coach Eduardo Berizzo after the match. Rodrigo Ramallo, Moises Angulo, Victor Abrego and Roberto Fernandez scored the goals. Bolivia rose to seventh place with 12 points, moving ahead of eighth-place Paraguay.
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